An anti-curare effect of hexamethonium at the mammalian neuromuscular junction
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چکیده
منابع مشابه
Synapse-glia interactions at the mammalian neuromuscular junction.
Perisynaptic Schwann cells (PSCs) play critical roles in regulating and stabilizing nerve terminals at the mammalian neuromuscular junction (NMJ). However, although these functions are likely regulated by the synaptic properties, the interactions of PSCs with the synaptic elements are not known. Therefore, our goal was to study the interactions between mammalian PSCs in situ and the presynaptic...
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It is now accepted that glial cells actively interact with neurons and modulate their activity in many regions of the nervous system. Importantly, modulation of synaptic activity by glial cells depends on the proper detection and decoding of synaptic activity. However, it remains unknown whether glial cells are capable of decoding synaptic activity and properties during early postdevelopmental ...
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Brief and chronic exposure of rats to neostigmine methylsulfate produced marked morphological alterations of the fine structure at the end-plate region of the extensor digitorum longus muscles. These changes were dose and time dependent and were restricted primarily to the subjunctional myofibrillar apparatus and membrane-bound organelles. In addition, significant presynaptic alterations were o...
متن کاملThe effect of centrophenoxine at the skeletal neuromuscular junction.
Centrophenoxine exhibited some interesting actions at the neuromuscular junction. The drug was ineffective in rat or chick preparations, but blocked neuromuscular transmission in frog preparations. The blockade was reversed by adrenaline, potassium, choline and physostigmine. The drug had no effect on muscle contractility or endplate cholinoceptor. Hemicholinium 3 induced a neuromuscular blocka...
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The effects of sodium thiopentone 19-757 mumol/litre, sodium pentobarbitone 25-806 mumol/litre, propanidid 74-1186 mumol/litre, Althesin 55-220 mumol/litre, diazepam 17.6-140 mumol/litre and ketamine 1.8-116.8 mumol/litre on the time-course of miniature end-plate currents of the excised mouse diaphragm were investigated. The currents were detected by means of extracellular electrodes and record...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1973
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1973.tb08333.x